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Repare Therapeutics Inc. (NASDAQ: RPTX) is a clinical-stage precision oncology company that utilizes its proprietary, genome-wide, CRISPR-enabled SNIPRx platform to systematically discover and develop highly targeted cancer therapies focused on genomic instability, including DNA damage repair. The company's lead product candidate, RPX-102, is a CRISPR-based gene editing therapy in development for the treatment of patients with solid tumors with BRCA1 or BRCA2 mutations. RPX-102 is designed to specifically target and repair BRCA1 and BRCA2 mutations, which are responsible for up to 20% of all breast and ovarian cancers. In preclinical studies, RPX-102 has shown promising activity in multiple tumor types, including breast, ovarian, and pancreatic cancer. Repare Therapeutics is also developing RPX-201, a CRISPR-based gene editing therapy in development for the treatment of patients with solid tumors with Fanconi anemia (FA). FA is a rare inherited disorder that causes patients to be highly susceptible to cancer. RPX-201 is designed to specifically target and repair FA mutations, which are responsible for the majority of FA-associated cancers. In preclinical studies, RPX-201 has shown promising activity in multiple tumor types, including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and solid tumors. In addition to RPX-102 and RPX-201, Repare Therapeutics is also developing a pipeline of other CRISPR-based gene editing therapies for the treatment of cancer. The company's pipeline includes programs targeting other genes that are associated with cancer, as well as programs targeting genes that are involved in the immune system. Repare Therapeutics was founded in 2016 by a team of scientists and entrepreneurs with expertise in CRISPR gene editing, cancer biology, and drug development. The company is headquartered in San Francisco, California. As of August 2023, Repare Therapeutics has raised over $500 million in funding. The company's investors include Flagship Pioneering, ARCH Venture Partners, Fidelity Management & Research Company, and Baillie Gifford. Repare Therapeutics is a leading player in the field of CRISPR gene editing for cancer therapy. The company has a strong pipeline of promising products, and its technology has the potential to revolutionize the treatment of cancer. Repare Therapeutics is well-positioned to become a major player in the precision oncology market. Here are some additional details about Repare Therapeutics:
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